Integrating Naltrexone

Combining Naltrexone with Professional Support

by Reframe Research Team • 3 min read

Naltrexone and professional support aren't competing approaches, but rather they’re complementary tools that address different aspects of change. Naltrexone changes what happens in your brain chemistry, while counseling resources can help you understand and work through your behavioral patterns differently to make long-lasting change in your life.

When used together, they create a powerful combination that's more effective than either approach alone. Let's explore why both matter and how they work together.

What Naltrexone Does for Your Brain


When you drink, alcohol triggers the release of endorphins, and these feel-good chemicals create feelings of pleasure and reward. Naltrexone is a medication that blocks the endorphin receptors in your brain so drinking produces significantly less pleasure.

Your Brain Gradually Unlearns


Over time, naltrexone weakens the learned connection between alcohol and reward. Your brain gradually stops seeing alcohol as a solution to stress, boredom, or discomfort. This happens at the brain chemistry level, without necessarily requiring conscious effort.

Naltrexone handles the neurochemical side of the equation, but that’s just one piece of an effective plan.

What Professional Support Does for Your Mind


While it can be extremely helpful, medication can't change your thoughts, beliefs, and emotional patterns that may lead you to reach for a drink in the first place. Maybe you learned to equate drinking with socializing. Maybe alcohol became your primary stress management tool. Maybe you have underlying anxiety or past experiences that you've been managing with alcohol.  Maybe it is all of these and more, and that’s okay. With proper support and tools, we can work to change how alcohol shows up in our lives. 

Building New Skills and Insights


While it can be extremely helpful, medication can't change your thoughts, beliefs, and emotional patterns that may lead you to reach for a drink in the first place. Maybe you learned to equate drinking with socializing. Maybe alcohol became your primary stress management tool. Maybe you have underlying anxiety or past experiences that you've been managing with alcohol.  Maybe it is all of these and more, and that’s okay. With proper support and tools, we can work to change how alcohol shows up in our lives. 


Professional support gives you the skills and understanding that medication alone can't provide.

Why Together Works Better


Studies consistently show that combining medication and professional guidance produces better outcomes than either approach alone. Research has found that people using both medication and behavioral support had significantly higher rates of sustained reduction in drinking compared to those using only one approach.

Creating Space to Practice New Skills


Here's why the combination is so effective: naltrexone creates neurochemical space by reducing the compulsive pull toward alcohol, making it easier to practice new skills. But without professional support, many people struggle to know what to do with that space. They might feel less drawn to drink, but they haven't developed alternative coping strategies or addressed underlying issues.

Conversely, expert guidance provides skills and insights, but changing behavior while fighting intense cravings and strong brain chemistry reinforcement is incredibly difficult. Naltrexone reduces that internal battle, making it easier to actually implement what you're learning.

How They Work Together


Think of it like treating a broken bone. You need both the cast (to hold everything in place while healing occurs) and physical therapy (to rebuild strength and mobility). Naltrexone is the cast: it creates the right conditions for healing. Working with a trained professional is the physical therapy: it rebuilds skills and addresses underlying issues.

The Synergistic Effect


When naltrexone reduces the reward from drinking, you have more mental and emotional bandwidth to engage with your support team. With the tools you get by using professional support for managing triggers and emotions, you're less likely to rely on alcohol even as the medication does its work.

Each approach makes the other more effective. That's the power of addressing both the biological and psychological aspects of change.

Making the Combination Work for You


Here are practical ways to maximize both approaches:

Addressing a Common Concern


Some people worry that using medication means they're not dealing with the "real" problem or that it's somehow taking the easy way out. This is a harmful misconception.

Changing your relationship with alcohol has both biological and psychological components. Your brain chemistry, thought patterns, and emotional responses are real. Addressing all of these isn't a weakness: it's comprehensive, intelligent treatment.

You Deserve Complete Support


Just as someone with diabetes needs both insulin and lifestyle changes, or someone with depression might benefit from both medication and therapy, addressing alcohol use from multiple angles isn't "cheating": it's giving yourself the best possible chance at lasting change.